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Buccutite FOL,马来酰亚胺 [FOLM]
物品单位 价格 品牌
2388 AAT Bioquest
  • 产地:American
  • 型号:2 umoles
  • 货号:CS5356
  • 发布日期: 2022-03-01
  • 更新日期: 2022-03-25
产品详细说明
产地 American
品牌 AAT Bioquest
货号 CS5356
用途范围 Research Grade
纯度 98%%
CAS编号
规格 2 umoles
是否进口

产品名称:Buccutite FOL,马来酰亚胺 [FOLM]

规格:2 umoles

储存条件:-15℃避光防潮

保质期:12个月

 

产品物理化学光谱特性

外观:固体

分子量:523.63

溶剂:DMSO

 

产品介绍

Buccutite 交联技术提供了最方便、最有效的交联方法,以高共轭产率连接两个生物分子。该方法使用一对交联剂:Buccutite MTA 和 Buccutite FOL。 MTA 被添加到一个分子中,而 FOL 被添加到另一个分子中。通过在中性条件下混合 Molecule-1-Buccutite MTA 和 Molecule-2-Buccutite FOL 来引发交联反应。Buccutite FOL 马来酰亚胺 (FOLM) 的使用方式与广泛用于交联蛋白质的 SMCC 相同。 FOLM 的一端(通过马来酰亚胺)与还原抗体(通过 TCEP 或 DTT)中发现的半胱氨酸硫醇 (-SH) 反应,以产生 FOL 修饰的还原抗体。 Buccutite 交联反应在极其温和和中性的条件下发生,不需要任何催化剂,而 SMCC 交联需要高浓度的蛋白质。此外,SMCC 修饰的蛋白质极不稳定,通常会自我反应,因为蛋白质通常同时含有胺和硫醇基团,这会导致大量的同交联。Buccutite 交联反应在极其温和和中性的条件下发生,无需任何催化剂,它比SMCC更加稳定高效。

 

参考文献

N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates.
Authors: Kasper, Marc-André and Gerlach, Marcus and Schneider, Anselm F L and Groneberg, Christiane and Ochtrop, Philipp and Boldt, Stefanie and Schumacher, Dominik and Helma, Jonas and Leonhardt, Heinrich and Christmann, Mathias and Hackenberger, Christian P R
Journal: Chembiochem : a European journal of chemical biology (2020): 113-119

MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides To Enable Labeling with 99mTc(I) Tricarbonyl Complex.
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2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation.
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Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
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Preparation and characterization of albumin conjugates of a truncated peptide YY analogue for half-life extension.
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Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation.
Authors: Lau, Shannen and Graham, Bim and Cao, Nga and Boyd, Ben J and Pouton, Colin W and White, Paul J
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Protein labeling with the labeling precursor [(18)F]SiFA-SH for positron emission tomography.
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Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds.
Authors: Lau, Shannen and Graham, Bim and Boyd, Ben J and Pouton, Colin W and White, Paul J
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Comparison of hydrazone heterobifunctional cross-linking agents for reversible conjugation of thiol-containing chemistry.
Authors: Christie, R James and Anderson, Diana J and Grainger, David W
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Synthesis, characterization and in vitro evaluation of a bone targeting delivery system for salmon calcitonin.
Authors: Bhandari, Krishna Hari and Newa, Madhuri and Uludag, Hasan and Doschak, Michael R
Journal: International journal of pharmaceutics (2010): 26-34


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