产品名称：SMPEG2

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：425.39

外观：固体

溶剂：DMSO

产品介绍

SM（PEG）2是具有17.6埃的胺-巯基交联剂。它具有可与氨基反应的NHS酯和可与巯基反应的马来酰亚胺。N-羟基琥珀酰亚胺酯（NHS）基团在pH 7-9时与赖氨酸和N端氨基发生特异而有效的反应，形成稳定的酰胺键。马来酰亚胺基团在pH 6.5-7.5下与还原的巯基反应形成稳定的硫醚键。SM（PEG）2用于通过柔性PEG间隔臂不可逆地交联蛋白质或肽。PEG臂有助于保持缀合物的溶解度，减少聚集和免疫原性的趋势。它是执行受控的两步蛋白偶联（如SMCC）的理想选择。

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