产品名称：SMPEG4

规格：25mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：513.50

外观：固体

溶剂：DMSO

产品介绍

SM（PEG）4是具有24.6埃的胺-巯基交联剂。它具有可与氨基反应的NHS酯和可与巯基反应的马来酰亚胺。N-羟基琥珀酰亚胺酯（NHS）基团在pH 7-9时与赖氨酸和N端氨基发生特异而有效的反应，形成稳定的酰胺键。马来酰亚胺基团在pH 6.5-7.5下与还原的巯基反应形成稳定的硫醚键。SM（PEG）4用于通过柔性PEG间隔臂不可逆地交联蛋白质或肽。PEG臂有助于保持缀合物的溶解度，减少聚集和免疫原性的趋势。它是执行受控的两步蛋白偶联（如SMCC）的理想选择。

参考文献

Cell encapsulation spatially alters crosslink density of poly(ethylene glycol) hydrogels formed from free-radical polymerizations.

Authors: Chu, Stanley and Maples, Mollie M and Bryant, Stephanie J
Journal: Acta biomaterialia (2020): 37-50

Crosslinker length dictates step-growth hydrogel network formation dynamics and allows rapid on-chip photoencapsulation.
Authors: Jiang, Zhongliang and Shaha, Rajib and McBride, Ralph and Jiang, Kun and Tang, Mingchen and Xu, Bang and Goroncy, Alexander K and Frick, Carl and Oakey, John
Journal: Biofabrication (2020): 035006

Enhanced regeneration of osteochondral defects by using an aggrecanase-1 responsively degradable and N-cadherin mimetic peptide-conjugated hydrogel loaded with BMSCs.
Authors: Feng, Xue and Zhou, Tong and Xu, Peifang and Ye, Juan and Gou, Zhongru and Gao, Changyou
Journal: Biomaterials science (2020): 2212-2226

Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives.
Authors: Shah, Ankur Harish and Djordjevic, Ivan and Steele, Terry W J
Journal: Journal of the mechanical behavior of biomedical materials (2020): 103405

A comparison of human mesenchymal stem cell osteogenesis in poly(ethylene glycol) hydrogels as a function of MMP-sensitive crosslinker and crosslink density in chemically defined medium.
Authors: Aziz, Aaron H and Bryant, Stephanie J
Journal: Biotechnology and bioengineering (2019): 1523-1536

An effective immobilized haloalkane dehalogenase DhaA from Rhodococcus rhodochrous by adsorption, crosslink and PEGylation on meso-cellular foam.
Authors: Zheng, He and Yu, Wei-Li and Guo, Xuan and Zhao, Yuan-Zhong and Cui, Yan and Hu, Tao and Zhong, Jin-Yi
Journal: International journal of biological macromolecules (2019): 1016-1023

Coaxial PCL/PEG-thiol-ene microfiber with tunable physico-chemical properties for regenerative scaffolds.
Authors: Iglesias-Echevarria, Monica and Durante, Luca and Johnson, Richard and Rafuse, Michael and Ding, Yonghui and Bonani, Walter and Maniglio, Devid and Tan, Wei
Journal: Biomaterials science (2019): 3640-3651

Datasets describing hydrogel properties and cellular metrics for modeling of tumor dormancy.
Authors: Pradhan, Shantanu and Slater, John H
Journal: Data in brief (2019): 104128

Dynamic control of hydrogel crosslinking via sortase-mediated reversible transpeptidation.
Authors: Arkenberg, Matthew R and Moore, Dustin M and Lin, Chien-Chi
Journal: Acta biomaterialia (2019): 83-95