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| 产地 | China |
| 货号 | CS00089 |
| 品牌 | Chemstan |
| 用途 | Research Grade |
| 型号 | |
| 外观 | |
| CAS编号 | 1228105-51-8 |
| 别名 | SMCC-DM1 |
| 级别 | 其他 |
| 重金属 | ppm |
| 英文名称 | DM1-SMCC |
| 包装规格 | 支 |
| 纯度 | 98% |
| 分子式 | C51H66ClN5O16S |
产品描述
SMCC-DM1 (DM1-SMCC) is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody drug conjugate (ADC).
靶点活性
Maytansinoids
体外活性
SMCC-DM1 inhibits HCC1954 and MDA-MB-468 cells proliferation with IC50s of 17.2 and 49.9 nM, respectively[1].
别名
SMCC-DM1
纯度
98%
分子量
1072.61
分子式
C51H66ClN5O16S
CAS No.
1228105-51-8
存储
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
溶解度
DMSO: 90 mg/mL (83.91 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
1. Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28(8):1363-1370.
Note
For research use only .
