物品单位 | 品牌 |
---|---|
支 | Chemstan |
产地 | China |
货号 | CS00038 |
品牌 | Chemstan |
用途 | Research Grade |
型号 | |
CAS编号 | 796073-69-3 |
别名 | 美登素 DM4, Ravtansine |
规格 | 支 |
级别 | 其他 |
外观性状 | |
产品英文名称 | DM4 |
重金属 | ppm |
纯度 | 98% |
分子式 | C38H54ClN3O10S |
产品描述
DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
靶点活性
Others
体外活性
DM4 is a cytotoxic maytansinoid drug and it is a structural analogue of maytansine. It also is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Which enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].
别名
美登素 DM4 , Ravtansine
纯度
98%
分子量
780.37
分子式
C38H54ClN3O10S
CAS No.
796073-69-3
存储
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
溶解度
DMSO: 99 mg/mL (126.86 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
Note
For research use only .
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