产品描述

DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. 

靶点活性

Others

体外活性

DM4 is a cytotoxic maytansinoid drug and it is a structural analogue of maytansine. It also is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Which enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1]. 

别名

美登素 DM4 , Ravtansine

纯度

98%

分子量

780.37 

分子式

C38H54ClN3O10S 

CAS No.

796073-69-3 

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 99 mg/mL (126.86 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

Note

For research use only .