产品描述

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.

靶点活性

Others

别名

化合物Mertansine , Maytansinoid DM1 , DM1 

纯度

98%

分子量

738.29 

分子式

C35H48ClN3O10S

CAS No.

139504-50-0

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

H2O: < 0.1 mg/mL (insoluble)

DMSO: 83.33 mg/mL (112.87 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Whiteman KR, et al. MAbs. 2014 Mar-Apr;6(2): 556-66.

2. Wang Y Q, Ji M Y, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy[J]. International Journal of Pharmaceutics. 2020: 119331.

Note

For research use only .