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产品展厅

Ansamitocin P-0
物品单位 品牌
Chemstan
  • 产地:China
  • 型号:
  • 货号:CS00034
  • cas:57103-68-1
  • 发布日期: 2022-07-26
  • 更新日期: 2022-07-28
产品详细说明
产地 China
货号 CS00034
品牌 Chemstan
用途 Research Grade
型号
CAS编号 57103-68-1
别名 Maytansinol, 美登醇
规格
级别 其他
外观性状
重金属 ppm
英文名称 Ansamitocin P-0
纯度 98%
分子式 C28H37ClN2O8

产品描述

Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro. 

靶点活性

Maytansinoids

体外活性

Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. 

别名

Maytansinol , 美登醇

纯度

98%

分子量

565.06 

分子式

C28H37ClN2O8

CAS No.

57103-68-1 

存储


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 35 mg/mL (61.94 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.

Note

For research use only .

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