产品描述
Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay). Mc-Val-Cit-PAB-Cl is a cleavable ADC linker.
靶点活性
Cleavable
别名
化合物Mc-Val-Cit-PAB-Cl
纯度
98%
分子量
591.1
分子式
C28H39ClN6O6
CAS No.
1639351-92-0
存储
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
参考文献
1. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.
Note
For research use only .