产品描述

Auristatin F is a potent cytotoxin. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC). 

靶点活性

Microtubule 

体外活性

Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin. Which is used in antibody-drug conjugates[1]. 

别名

澳瑞他汀 F

分子量

745.99

分子式

C40H67N5O8 

CAS No.

163768-50-1 

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 56 mg/mL (75.07 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Roy S, et al. SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. Chem Commun (Camb). 2017 Apr 11;53(30):4234-4237.

Note

For research use only .