产品描述

Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE . MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization[1]. 

靶点活性

Auristatin 

别名

化合物Val-Cit-PAB-MMAE 

纯度

98%

分子量

1123.43

分子式

C58H94N10O12

CAS No.

644981-35-1 

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 49 mg/mL (43.61 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

Note

For research use only .