产品描述

Anastrozole(ZD1033), a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM), has no obvious effect on adrenocorticoid hormone synthesis.

靶点活性

Aromatase

激酶实验

Aromatase inhibition is measured using human placental microsomes and the method of Thompson and Siiteri with Testosterone (0.5 μM) as substrate. 11-hydroxylase inhibition is determined by measuring the conversion of [1,2,6,7-3H]-ll-deoxy- cortisol to cortisol using freshly prepared mitochondria from guinea pig, dog and cow adrenal glands. Reaction products are extracted into chloroform and separated by thin layer chromatography[1].

别名

阿那曲唑 , ZD1033

纯度

98%

分子量

293.37

分子式

C17H19N5

CAS No.

120511-73-1

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 29.3 mg/mL (100 mM)

Ethanol: 29.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Dukes M, et al. J Steroid Biochem Mol Biol, 1996, 58(4), 439-445.

2. Plourde PV, et al. Breast Cancer Res Treat, 1994, 30(1), 103-111.

Note

For research use only.