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产品展厅

N6-Methyladenosine N6-甲基腺苷
物品单位 品牌
Chemstan
  • 产地:China
  • 型号:
  • 货号:CS00422
  • cas:1867-73-8
  • 发布日期: 2022-08-01
  • 更新日期: 2022-08-03
产品详细说明
产地 China
货号 CS00422
品牌 Chemstan
用途 Research Grade
型号
CAS编号 1867-73-8
别名 N6-甲基腺苷 , N-Methyladenosine , 6-Methyladenosine , NSC-29409 , m6A , NSC-29409
规格
级别 其他
外观性状
重金属 ppm
英文名称 N6-Methyladenosine
纯度 98%
分子式 C11H15N5O4

产品描述

N6-Methyladenosine is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological markers for patients with colorectal cancer.

靶点活性

Others

体外活性

N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. [1] [2] [3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). [4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3'UTRs in both mouse and human mRNAs. [5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. [6]

体内活性

LD50: Mice >1 g/kg (i.g.). [7]

别名

N6-甲基腺苷 , N-Methyladenosine , 6-Methyladenosine , NSC-29409 , m6A , NSC-29409 

纯度

98%

分子量

281.27

分子式

C11H15N5O4

CAS No.

1867-73-8

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 56 mg/mL (199.09 mM)

Ethanol: 2 mg/mL (7.11 mM)

Water: 14 mg/mL (49.77 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

6. Jia G, et al. Nat Chem Biol, 2011, 7(12), 885-887.

7. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8.

8. Zhou L, Tang R, Li X, et al. N6-methyladenosine RNA modification regulates strawberry fruit ripening in an ABA-dependent manner[J]. bioRxiv. 2021

9. Zhou L, Tian S, Qin G. RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening. genome biology. 2019, 20(1): 1-23.

Note

For research use only.

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