产品描述

N6-Methyladenosine is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological markers for patients with colorectal cancer.

靶点活性

Others

体外活性

N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. [1] [2] [3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). [4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3'UTRs in both mouse and human mRNAs. [5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. [6]

体内活性

LD50: Mice >1 g/kg (i.g.). [7]

别名

N6-甲基腺苷 , N-Methyladenosine , 6-Methyladenosine , NSC-29409 , m6A , NSC-29409 

纯度

98%

分子量

281.27

分子式

C11H15N5O4

CAS No.

1867-73-8

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 56 mg/mL (199.09 mM)

Ethanol: 2 mg/mL (7.11 mM)

Water: 14 mg/mL (49.77 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

6. Jia G, et al. Nat Chem Biol, 2011, 7(12), 885-887.

7. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8.

8. Zhou L, Tang R, Li X, et al. N6-methyladenosine RNA modification regulates strawberry fruit ripening in an ABA-dependent manner[J]. bioRxiv. 2021

9. Zhou L, Tian S, Qin G. RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening. genome biology. 2019, 20(1): 1-23.

Note

For research use only.