产品描述

Cytidine is a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond. Cytidine is a precursor for uridine. Both cytidine and uridine are utilized in RNA synthesis.

靶点活性

Nucleoside Analogue

体内活性

D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5]

别名

胞苷 , Cytosine-1-β-D-ribofuranoside , Cytosine β-D-riboside

纯度

98%

分子量

243.22

分子式

C9H13N3O5

CAS No.

65-46-3

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 46 mg/mL (189.1 mM)

Water: 45 mg/mL (185 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Jonas DA, et al. Ann Nutr Metab. 2001; 45(6):235-54.

Note

For research use only.