2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.
2'-Deoxy-2'-fluorocytidine (EC50 = 61 ± 18 nM) has 200 × the potency of ribavirin (EC50 = 12.5 ± 2.6 μM), as well as 17 × the potency of T-705 (favipiravir), another compound with reported anti-CCHFV activity (EC50 = 1.03 ± 0.16 μM). 2'-Deoxy-2'-fluorocytidine acts synergistically with T-705 to inhibit CCHFV replication without causing cytotoxicity.
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 5 mg/mL (20.39 mM), ultrasonic and warming and heat to 60°C
( < 1 mg/ml refers to the product slightly soluble or insoluble )
1. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
For research use only.