产品描述

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

别名

2'-氟-2'-脱氧腺苷 

纯度

98%

分子量

269.23

分子式

C10H12FN5O3

CAS No.

64183-27-3

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 50 mg/mL (185.71 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.

Note

For research use only.