15926423062  

产品展厅

Ixazomib citrate 枸橼酸艾沙佐米
物品单位 品牌
Chemstan
  • 产地:China
  • 型号:
  • 货号:CS02987
  • cas:1239908-20-3
  • 发布日期: 2022-08-01
  • 更新日期: 2022-08-01
产品详细说明
产地 China
货号 CS02987
品牌 Chemstan
用途 Research Grade
型号
CAS编号 1239908-20-3
别名 化合物Ixazomib citrate, MLN9708, 枸橼酸艾沙佐米
规格
级别 其他
外观性状
产品英文名称 Ixazomib citrate
重金属 ppm
纯度 98%
分子式 C20H23BCl2N2O9

产品描述

Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.

靶点活性

20S proteasome β5    20S proteasome β1    20S proteasome β2

体外活性

Treatment of MM cells with MLN2238 predominantly inhibits chymotrypsin-like activity of the proteasome and induces accumulation of ubiquitinated proteins. MLN2238 inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies without affecting the viability of normal cells[1].

体内活性

In animal tumor model studies, MLN2238 is well tolerated and inhibits tumor growth with significantly reduced tumor recurrence. A head-to-head analysis of MLN2238 versus bortezomib showed a significantly longer survival time in mice treated with MLN2238 than mice receiving bortezomib[1].

别名

化合物Ixazomib citrate , MLN9708 , 枸橼酸艾沙佐米

纯度

98%

分子量

517.12

分子式

C20H23BCl2N2O9

CAS No.

1239908-20-3

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

溶解度

DMSO: 100 mg/mL (193.38 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Note

For research use only.

< 返回前一个页面 >





联系方式
手机:15926423062
电话:15926423062
手机访问官网

15926423062

武汉科斯坦生物科技有限公司 版权所有(C)2022  XML 技术支持: 食品商务网   盖德化工网  

武汉科斯坦生物科技有限公司