产品描述

Ganciclovir is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

靶点活性

FHV-1

体内活性

In a’dult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In a’dult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice[7].

别名

更昔洛韦 , 2'-Nor-2'-deoxyguanosine , BW 759 , RS-21592
纯度

99.55%
分子量

255.23
分子式

C₉H₁₃N₅O₄
CAS No.

82410-32-0

存储
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
溶解度
DMSO: 50 mg/mL (195.9 mM)
Ethanol: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )

参考文献

1. Matthews T, et al. Rev Infect Dis, 1988, 10, S490-494.

2. Hamel W, et al. Cancer Res, 1996, 56(12), 2697-2702.

3. St Clair MH, et al. Antimicrob Agents Chemother, 1987, 31(6), 844-849.

4. Wei SJ, et al. Exp Cell Res, 1998, 241(1), 66-75.

5. Rubsam LZ, et al. Cancer Res, 1998, 58(17), 3873-3882.

6. BoujemLa I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5.

7. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease[J]. Cell Death & Differentiation. 2021: 1-19.

8. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response[J]. Molecular cell. 2019 Mar 7;73(5):946-958.e7.

9. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells[J]. Molecular cell. 2017 Nov 2;68(3):615-625.e9.