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产品展厅

Tylvalosin 爱乐新
物品单位 品牌
Chemstan
  • 产地:China
  • 型号:
  • 货号:CS00336
  • cas:63409-12-1
  • 发布日期: 2022-08-04
  • 更新日期: 2022-08-04
产品详细说明
产地 China
货号 CS00336
品牌 Chemstan
用途 Research Grade
型号
CAS编号 63409-12-1
别名 爱乐新
规格
级别 其他
外观性状
产品英文名称 Tylvalosin
重金属 ppm
纯度 ≥95%%
分子式 C53H87NO19

产品描述

A new macrolide antibiotic

生物活性

Tylvalosin is a macrolide antibiotic. It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 μg/ml, respectively). Tylvalosin (5 and 10 μg/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 (PGE2), and nitric oxide in RAW 264.7 cells. It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water. Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.

别名

爱乐新

纯度

≥95%

分子量

1042.25

分子式

C53H87NO19

CAS No.

63409-12-1

存储

Store in a tight container at -20℃.

参考文献

[1] Moges R, De Lamache DD, Sajedy S, Renaux BS, Hollenberg MD, Muench G, Abbott EM, Buret AG. Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB(4) Production, While Inducing the Release of Pro-Resolving Lipoxin A(4) and Resolvin D1. Front Vet Sci. 2018 Apr 11;5:57. doi: 10.3389/fvets.2018.00057. eCollection 2018. PubMed PMID: 29696149; PubMed Central PMCID: PMC5905233.

[2] Pallarés FJ, Lasa C, Roozen M, Ramis G. Use of tylvalosin in the control of porcine enzootic pneumonia. Vet Rec Open. 2015 Jun 30;2(1):e000079. doi: 10.1136/vetreco-2014-000079. eCollection 2015. PubMed PMID: 26392896; PubMed Central PMCID: PMC4567154.

Note

For research use only.

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