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产品展厅

Aclacinomycin 阿克拉霉素
物品单位 品牌
Chemstan
  • 产地:China
  • 型号:
  • 货号:CS00390
  • cas:66676-88-8
  • 发布日期: 2022-08-04
  • 更新日期: 2022-08-05
产品详细说明
产地 China
货号 CS00390
品牌 Chemstan
用途 Research Grade
型号
CAS编号 66676-88-8
别名 Siwenmycin ,阿克拉霉素
规格
级别 其他
外观性状
重金属 ppm
英文名称 Aclacinomycin
纯度 ≥95%%
分子式 C30H35NO10

产品描述

Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.

别名

Siwenmycin ,阿克拉霉素

纯度

≥95%

分子量

569.61

分子式

C30H35NO10

CAS No.

66676-88-8

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

参考文献

1. Bundale S, Begde D, Pillai D, Gangwani K, Nashikkar N, Kadam T, Upadhyay A. Novel aromatic polyketides from soil Streptomyces spp.: purification, characterization and bioactivity studies. World J Microbiol Biotechnol. 2018 Apr 24;34(5):67. doi: 10.1007/s11274-018-2448-1. PubMed PMID: 29691661.

2. Lee YL, Chen CW, Liu FH, Huang YW, Huang HM. Correction: Aclacinomycin A Sensitizes K562 Chronic Myeloid Leukemia Cells to Imatinib through p38MAPK-Mediated Erythroid Differentiation. PLoS One. 2017 Oct 11;12(10):e0186528. doi: 10.1371/journal.pone.0186528. eCollection 2017. PubMed PMID: 29020096; PubMed Central PMCID: PMC5636156.

3. Ye YB, Xu XJ, Chen YH, Zhang MW, Qiu DF, Guo ZW, He HQ. [Synergistic lethal effect of combined treatment of arsenic trioxide and aclacinomycin on human acute myeloid leukemia cell line KG-1a]. Zhonghua Zhong Liu Za Zhi. 2017 Apr 23;39(4):256-262. doi: 10.3760/cma.j.issn.0253-3766.2017.04.004. Chinese. PubMed PMID: 28550664.

4. Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. J Autoimmun. 2017 Jul;81:13-23. doi: 10.1016/j.jaut.2017.03.001. Epub 2017 Mar 18. PubMed PMID: 28325644; PubMed Central PMCID: PMC5558601.

Note

For research use only.

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