产品描述

Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.

别名

Siwenmycin ,阿克拉霉素

纯度

≥95%

分子量

569.61

分子式

C30H35NO10

CAS No.

66676-88-8

存储

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

参考文献

1. Bundale S, Begde D, Pillai D, Gangwani K, Nashikkar N, Kadam T, Upadhyay A. Novel aromatic polyketides from soil Streptomyces spp.: purification, characterization and bioactivity studies. World J Microbiol Biotechnol. 2018 Apr 24;34(5):67. doi: 10.1007/s11274-018-2448-1. PubMed PMID: 29691661.

2. Lee YL, Chen CW, Liu FH, Huang YW, Huang HM. Correction: Aclacinomycin A Sensitizes K562 Chronic Myeloid Leukemia Cells to Imatinib through p38MAPK-Mediated Erythroid Differentiation. PLoS One. 2017 Oct 11;12(10):e0186528. doi: 10.1371/journal.pone.0186528. eCollection 2017. PubMed PMID: 29020096; PubMed Central PMCID: PMC5636156.

3. Ye YB, Xu XJ, Chen YH, Zhang MW, Qiu DF, Guo ZW, He HQ. [Synergistic lethal effect of combined treatment of arsenic trioxide and aclacinomycin on human acute myeloid leukemia cell line KG-1a]. Zhonghua Zhong Liu Za Zhi. 2017 Apr 23;39(4):256-262. doi: 10.3760/cma.j.issn.0253-3766.2017.04.004. Chinese. PubMed PMID: 28550664.

4. Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. J Autoimmun. 2017 Jul;81:13-23. doi: 10.1016/j.jaut.2017.03.001. Epub 2017 Mar 18. PubMed PMID: 28325644; PubMed Central PMCID: PMC5558601.

Note

For research use only.