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产品展厅

Sorafenib
物品单位 价格 品牌
315 Chemstan
  • 产地:China
  • 型号:10mg
  • 货号:CSGC17369
  • cas:284461-73-0
  • 发布日期: 2022-10-10
  • 更新日期: 2022-10-12
产品详细说明
产地 China
品牌 Chemstan
货号 CSGC17369
用途范围 Research Grade
英文名称 Sorafenib
纯度 >98%%
CAS编号 284461-73-0
规格 10mg
保质期
是否进口
产品描述
Sorafenib is an oral multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit. sorafenib, inhibits tumor growth and disrupts tumor microvasculature through antiproliferative, antiangiogenic, and/or proapoptotic effects. sorafenib blocks Raf kinase signaling, inhibits tumor cell proliferation, and induces apoptosis in vitro. In addition, sorafenib exhibits robust antitumor efficacy.
References
1. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. L Liu, Y Cao, C Chen, X Zhang, A McNabola, D Wilkie  Cancer research, 2006
2. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. GK Abou-Alfa, L Schwartz, S Ricci. Journal of clinical Oncology. 2006
Chemical Properties

Cas No.

284461-73-0

SDF

别名

BAY-43-9006,Sorafenib,Nexavar,sorafenibum

化学名

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide

Canonical SMILES

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

分子式

C21H16ClF3N4O3

分子量

464.82

溶解度

≥ 23.25mg/mL in DMSO

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

Purity:

>99.50%

Note
For research use only .

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