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Thalidomide-4-NH-PEG2-COOH
物品单位 价格 品牌
2000 Chemstan
  • 产地:China
  • 型号:25mg
  • 货号:CSJY031
  • cas:2140807-17-4
  • 发布日期: 2022-11-09
  • 更新日期: 2023-02-07
产品详细说明
产地 China
品牌 Chemstan
货号 CSJY031
用途范围 Research Grade
纯度 >95%%
CAS编号 2140807-17-4
规格 25mg
是否进口
中文名称:泊马度胺-二聚乙二醇-酸

Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) 是一种合成的 E3 连接酶配体-linker 偶联物,它包含基于 Pomalidomide 的 cereblon 配体和连接子。Pomalidomide-PEG2-COOH 可用于 PROTAC 合成。


生物活性:
Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

体外研究(In Vitro):
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量:
433.41

Formula:
C20H23N3O8

CAS 号:
2140807-17-4

运输条件:
Room temperature in continental US; may vary elsewhere.

储存方式:
4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

参考文献:
[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.  Content Brief

Note:
For research use only .

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