(S,R,S)-AHPC-Boc (VH032-Boc) 是一种用于募集 von-Hippel-Lindau (VHL) 蛋白配体。(S,R,S)-AHPC-Boc 用于 PROTAC 技术。

生物活性
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology[1].

IC50 & Target[1]: VHL

体外研究:(In Vitro)
The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional PROTACs to induce ubiquitination and subsequent proteasomal degradation of a target protein.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量:
530.68

Formula:
C27H38N4O5S

CAS 号:
1448189-98-7

运输条件:
Room temperature in continental US; may vary elsewhere.

储存方式:
-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献:
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015;10(8):1770‐1777.  Content Brief


Note：
For research use only .