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VH032-NH-CO-CH2-Br
物品单位 价格 品牌
700 Chemstan
  • 产地:China
  • 型号:100mg
  • 货号:CSJY036
  • cas:2379404-33-6
  • 发布日期: 2022-11-09
  • 更新日期: 2023-02-03
产品详细说明
产地 China
品牌 Chemstan
货号 CSJY036
用途范围 Research Grade
纯度 >95%%
CAS编号 2379404-33-6
规格 100mg
是否进口

中文别名:(S,R,S)-AHPC-CO-CI-Br

沸点:804.8±65.0 °C(Predicted)

密度:1.408±0.06 g/cm3(Predicted)


生物活性:
(S,R,S)-AHPC-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target:VHL

体外研究:(In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量:
551.50

Formula:
C24H31BrN4O4S

CAS 号:
2379404-33-6

运输条件:
Room temperature in continental US; may vary elsewhere.

储存方式:
Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献:
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.  Content Brief

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.  Content Brief

Note:
For research use only .

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