中文别名:（S,R,S)-AHPC-CO-CI-Br

沸点:804.8±65.0 °C(Predicted)

密度:1.408±0.06 g/cm3(Predicted)

生物活性：
(S,R,S)-AHPC-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target：VHL

体外研究：(In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量：
551.50

Formula：
C24H31BrN4O4S

CAS 号：
2379404-33-6

运输条件：
Room temperature in continental US; may vary elsewhere.

储存方式：
Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献：
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.  Content Brief

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.  Content Brief

Note：
For research use only .