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VH-298
物品单位 价格 品牌
1200 Chemstan
  • 产地:China
  • 型号:5mg
  • 货号:CSJY040
  • cas:2097381-85-4
  • 发布日期: 2022-11-09
  • 更新日期: 2022-11-09
产品详细说明
产地 China
品牌 Chemstan
货号 CSJY040
用途范围 科研用对照品
纯度 >98%%
CAS编号 2097381-85-4
规格 5mg
是否进口

中文名称:VH298

VH-298 是一种高效的 VHL:HIF-α 相互作用抑制剂(Kd:80-90 nM)。它可用于PROTAC技术中。


CAS No:2097381-85-4


产品描述:
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.

体外活性:

VH298, a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.?We show that VH298 engages with high affinity and specificity with VHL as its only major cellular target, leading to selective on-target accumulation of hydroxylated HIF-α in a concentration- and time-dependent fashion in different cell lines, with subsequent upregulation of HIF-target genes at both mRNA and protein levels.?VH298 represents a high-quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling.


分子式:
C27H30N5O4S

分子量:
523.65

参考文献:
[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.

储存和溶解度:
DMSO:78.3mg/ml (149.53 Mm)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

Note:
For research use only .

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