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Thalidomide-4-NH-PEG2-NH2 TFA
  • 品牌:Chemstan
  • 产地:China
  • 型号:100mg
  • 货号:CSJY025
  • cas:2097509-36-7
  • 价格: ¥1000/支
  • 发布日期: 2022-11-09
  • 更新日期: 2024-04-30
产品详请
产地 China
品牌 Chemstan
货号 CSJY025
用途范围 科研用对照品
纯度 >95%%
CAS编号 2097509-36-7
规格 100mg
是否进口
产品描述:
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].


体外活性:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.


分子式:

C21H25F3N4O8


分子量:

518.446


别名:

Thalidomide-NH-PEG2-C2-NH2 TFA


参考文献:

[1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.


储存和溶解度:

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years

In solvent: -80°C for 2 years


Note:

For research use only .

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