产品描述
RR-11a analog is an inhibitor of asparaginyl endopeptidase with IC50s of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively.

体内活性
RR-11a analog shows a t1/2 of 3-10 min[2].

Cas No.
685543-66-2

分子式
C22H29N5O8

分子量
491.49

别名
aza-peptide Michael acceptor, 7a

参考文献
[1]G?tz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.
[2]Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.

储存和溶解度
DMSO:112.5mg/mL (228.9mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

Note
For research use only .