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Darbufelone
  • 品牌:TargetMol
  • 产地:China
  • 型号:1mg
  • 货号:T10960
  • cas:139226-28-1
  • 价格: ¥1767/支
  • 发布日期: 2023-02-21
  • 更新日期: 2024-06-21
产品详请
产地 China
品牌 TargetMol
货号 T10960
用途 Research Grade
纯度 >98%%
CAS编号 139226-28-1
规格 1mg
是否进口
产品描述
Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.


体外活性
Darbufelone (5 - 60 μM) increases the cell growth inhibitory effects in A549, H520 and H460 cell lines with IC50s of 20, 21 and 15 μM[2].


体内活性
Darbufelone (80 mg/kg/day) decreases the tumor volumes in a time-dependent manner. Darbufelone (20 or 40 mg/kg/day) dos not show any significant inhibition of tumor weight. At necropsy, Darbufelone (80 mg/kg/day) reduces the tumor weight by 30.2%[2].


Cas No.
139226-28-1


分子式
C18H24N2O2S


分子量
332.46


别名
CI-1004;达布非酮


参考文献
[1]Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45.
[2]Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85.


储存和溶解度
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years


Note
For research use only .

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