Darbufelone
- 价格: ¥1767/支
- 发布日期: 2023-02-21
- 更新日期: 2023-09-28
产品详请
产地 |
China
|
品牌 |
TargetMol
|
货号 |
T10960
|
用途范围 |
Research Grade
|
纯度 |
>98%%
|
CAS编号 |
139226-28-1
|
规格 |
1mg
|
是否进口 |
否
|
产品描述
Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.
体外活性
Darbufelone (5 - 60 μM) increases the cell growth inhibitory effects in A549, H520 and H460 cell lines with IC50s of 20, 21 and 15 μM[2].
体内活性
Darbufelone (80 mg/kg/day) decreases the tumor volumes in a time-dependent manner. Darbufelone (20 or 40 mg/kg/day) dos not show any significant inhibition of tumor weight. At necropsy, Darbufelone (80 mg/kg/day) reduces the tumor weight by 30.2%[2].
Cas No.
139226-28-1
分子式
C18H24N2O2S
分子量
332.46
别名
CI-1004;达布非酮
参考文献
[1]Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45.
[2]Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85.
储存和溶解度
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Note
For research use only .