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PF-9184
  • 品牌:TargetMol
  • 产地:China
  • 型号:1mg
  • 货号:T21738
  • cas:1221971-47-6
  • 价格: ¥648/支
  • 发布日期: 2023-02-21
  • 更新日期: 2024-04-15
产品详请
产地 China
品牌 TargetMol
货号 T21738
用途范围 Research Grade
纯度 >98%%
CAS编号 1221971-47-6
规格 1mg
是否进口
产品描述
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.


体外活性
PF-9184 (0.015-100 μM; 24 hours) inhibits IL-1β-stimulated prostaglandin E2 (PGE2) synthesis in rheumatoid arthritis (RASF) in synovial fibroblasts derived from patients and has no apparent cytotoxic effects. PF-9184 (0.015-100 μM) potently blocks mPGES-1 ability to synthesize PGE2 from PGH2, and with no apparent inhibitory effects on COX-2 and prostacyclin synthase in cells. PF-9184 (0.015-100 μM) inhibits PGE2 weakly but has no effect on TXB2 synthesis except at 100 μM in human whole blood and modified blood assays. PF-9184 is a poor inhibitor of recombinant rat mPGES-1 (IC50=1080±398 nM)[1].


体内活性
PF-9184 (oral administration or even local delivery) has no effect on PGE2 synthesis in recombinant rats[1].


Cas No.
1221971-47-6


分子式
C21H14Cl2N2O4S


分子量
461.32


参考文献
[1]Gabriel M, et, al. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem Pharmacol. 2010 May 15; 79(10): 1445-54.


储存和溶解度
DMSO:10 mg/mL (21.7 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years


Note
For research use only .

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