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产地 | China |
品牌 | Chemstan |
货号 | CST26912 |
用途范围 | Research Grade |
纯度 | >95% by SDS-PAGE.% |
规格 | 100ug |
是否进口 | 否 |
Catalog Number: CST26912 |
Gene Symbol: RAP1 |
Description: Anti Active Rap1 Mouse Monoclonal Antibody |
Background: Small GTPases are a super-family of cellular signaling regulators. Rap family members (Rap1A, Rap1B, Rap2A, Rap2B, and Rap2C) are Ras-like GTPases that regulate cell proliferation, differentiation, apoptosis and adhesion mechanisms. Rap1 (Ras-proximate-1) regulates apoptosis through interaction with two MAP3K effectors of the MEK/ERK MAP-kinase pathway, Raf-1 and B-Raf. Rap1 regulates cell adhesion mechanisms through effector molecules such as the integrins and cadherins. |
Immunogen: Recombinant full length protein of active Rap1. |
Applications: IP, IHC |
Recommended Dilutions: 1 μg for 1~2 mg total cellular proteins for IP 1:100 dilution for IHC |
Concentration: 1 mg/ml |
Host: mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Storage buffer: |
Preservative: no |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Anti-active Rap1 antibody recognizes active Rap1 of vertebrates. |
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles |
Immunoprecipitation/Western blot: |
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Rap1 activation assay. Purified Rap1 proteins were immunoprecipitated after treated with GDP (lane 1) or GTPγS (lane 2). Immunoprecipitation was done with the anti-active Rap1 monoclonal antibody (Cat. No. 26912). Immunoblot was with an anti-Rap1 polyclonal antibody (Cat. No. 21104). |
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