GW6471-武汉科斯坦生物科技有限公司

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GW6471

品牌：Chemstan

产地：China

型号：5mg

货号：CST8486

价格： ￥497/支
发布日期： 2024-01-03
更新日期： 2024-05-07

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产地	China
品牌	Chemstan
货号	CST8486
用途范围	Research Grade
纯度	%
规格	5mg
是否进口	否

产品描述

GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.

体外活性

A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4;?this data was confirmed as specific to PPARα antagonism by siRNA methods.

别名

GW 6471

分子量

619.67

分子式

C35H36F3N3O4

CAS No

880635-03-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

DMSO: 120 mg/mL (193.65 mM), Need ultrasonic

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Abu Aboud O, et al. Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysisinhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115.

2. Xu HE, et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7.

3. Abu Aboud O, et al. PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C890-8.

Note

For research use only.

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