生物活性
Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]
Human Endogenous Metabolite

体外研究
(In Vitro)
Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM
Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19


体内研究
(In Vivo)
Chronic Nicotinamide riboside Chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner

分子量
290.70

Formula
C11H15ClN2O5

CAS 号
23111-00-4

性状
固体

颜色
White to yellow

中文名称
烟酰胺核糖氯酸盐

结构分类
AlkaloidsPyridine Alkaloids
初始来源
milk and beer

运输条件
Room temperature in continental US; may vary elsewhere.

储存方式
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Note
For research use only .