Catalog No.

CS016016

Species reactivity 

Human

Applications

Research Grade Biosimilar

Host species 

Humanized

Isotype 

IgG4-Kappa

Expression system 

Mammalian Cells

Clonality 

Monoclonal

Target 

IL7R, Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL-7 receptor subunit alpha, CD127, CDw127, IL-7R subunit alpha, IL-7RA

Endotoxin level 

Please contact the lab for this information.

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G, purified from cell culture supernatant.

Accession 

P16871

Form 

Liquid

Storage buffer

0.01M PBS,pH7.4.

Stability and Storage 

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -698°C.

Alternate Names

Effi-7,Effi7-h,MD-707,CAS:2375835-91-7

Background

Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research.

Note 

For research use only. Not for use in clinical or therapeutic applications.