Catalog No. 

CS061046

Species reactivity 

Human

Applications 

Research Grade Biosimilar

Host species 

Human

Isotype 

IgG1-lambda

Expression system

Mammalian Cells

Clonality

Monoclonal

Target 

IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor

Endotoxin level

Please contact the lab for this information.

Purity 

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G, purified from cell culture supernatant.

Accession

P55899

Form

Liquid

Storage buffer 

0.01M PBS,pH7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -369°C.

Alternate Names 

M-281,M281,CAS:2211985-36-1

Background 

Nipocalimab (M281) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6.

Note 

For research use only. Not for use in clinical or therapeutic applications.