Catalog No.

CS310016

Species reactivity

Human

Applications 

Research Grade Biosimilar

Host species

Humanized

Isotype

IgG1-kappa

Expression system

Mammalian Cells

Clonality 

Monoclonal

Target

GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5

Concentration

2.2mg/ml

Endotoxin level 

Please contact the lab for this information.

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G, purified from cell culture supernatant.

Accession

P51654

Form 

Liquid

Storage buffer 

0.01M PBS,pH7.4.

Stability and Storage 

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -434°C.

Alternate Names 

GC33,RG7686,RO5137382,CAS:1365267-33-9

Background

Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (Kd of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth.

Note 

For research use only. Not for use in clinical or therapeutic applications.