Catalog No. 

CS036016

Species reactivity 

Human

Applications 

Research Grade Biosimilar

Host species 

Humanized

Isotype 

IgG1-kappa

Expression system 

Mammalian Cells

Clonality 

Monoclonal

Target 

Transferrin receptor protein 1, TfR1, T9, Trfr, p90, CD71, TFRC, TfR, sTfR, TR

Endotoxin level 

Please contact the lab for this information.

Purity 

>95% purity as determined by SDS-PAGE.

Purification 

Protein A/G, purified from cell culture supernatant.

Accession

P02786

Form 

Liquid

Storage buffer

0.01M PBS,pH7.4.

Stability and Storage 

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -137°C.

Alternate Names 

JR-141,CAS:2140211-48-7

Background

Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.

Note 

For research use only. Not for use in clinical or therapeutic applications.