Catalog No. 

CS115026

Species reactivity 

General

Applications 

Research Grade Biosimilar

Host species 

Chimeric

Isotype

IgG1-kappa

Expression system

Mammalian Cells

Clonality

Monoclonal

Target 

Ganglioside GD2

Concentration 

1mg/ml

Endotoxin level 

Please contact the lab for this information.

Purity 

>95% purity as determined by SDS-PAGE.

Purification 

Protein A/G, purified from cell culture supernatant.

Accession 

CAS: 65988-71-8

Form

Liquid

Storage buffer 

0.01M PBS,pH7.4.

Stability and Storage 

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -1439°C.

Alternate Names 

14.18mAb,14.18-IL-2,EMD273063,EMD-273063,Hu14.18-IL-2,Hu14.18-IL2,anti-GD2fusedtoIL2,hu14.18-IL2,hu14.18-Interleukin-2fusionprotein,CAS:2131168-99-3

Background

Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity.

Note 

For research use only. Not for use in clinical or therapeutic applications.